Randomised controlled trial of tetanus treatment with antitetanus immunoglobulin by the intrathecal or intramuscular route
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منابع مشابه
Randomised controlled trial of tetanus treatment with antitetanus immunoglobulin by the intrathecal or intramuscular route.
OBJECTIVE To evaluate the effect of intrathecal therapy with human antitetanus immunoglobulin on clinical progression of and mortality from tetanus. DESIGN Randomised controlled trial. SETTING Intensive care unit of a university hospital, Pernambuco, Brazil. PARTICIPANTS 120 patients with tetanus allocated to antitetanus immunoglobulin by either the intrathecal and intramuscular route (n ...
متن کاملIntrathecal vs. intramuscular administration of human antitetanus immunoglobulin or equine tetanus antitoxin in the treatment of tetanus: a meta-analysis.
BACKGROUND Mortality caused by tetanus is still a serious health problem in developing countries. Apart from immunization, early treatment with equine antitetanus serum (ATS) or human tetanus immunoglobulin (TIG) is the real treatment that can avoid death. On pathophysiological grounds intrathecal administration would be preferred because of high concentrations of the antiserum in cerebrospinal...
متن کاملIntrathecal antitetanus serum (horse) with steroid in the treatment of neonatal tetanus.
107 patients with neonatal tetanus were studied and the value of intrathecal antitetanus serum with steroid was noted. The mortality rate in a control group (68%) was significantly higher than that of the test group (37%). Furthermore, a delay in antitetanus serum administration was found to have a strong positive linear correlation with the mortality rate. In fact, the mortality rate for neona...
متن کاملIntrathecal antitetanus serum ( horse ) with steroid in the treatment of neonatal tetanus ARUN
107 patients with neonatal tetanus were studied and the value of intrathecal antitetanus serum with steroid was noted. The mortality rate in a control group (68%) was significantly higher than that ofthe test group (37%). Furthermore, a delay in antitetanus serum administrationwas found to have a strong positive linear correlation with the mortality rate. In fact, the mortality rate for neonate...
متن کاملIntrathecal anti-tetanus human immunoglobulin in the treatment of neonatal tetanus.
OBJECTIVE To determine the outcome of tetanus in neonates treated with intrathecal tetanus immunoglobulin in terms of mortality and hospital stay. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Paediatric Unit I, Bahawal Victoria Hospital, Bahawalpur, from April 2004 to December 2007. METHODOLOGY Seventy neonates with diagnosis of neonatal tetanus were included in the study....
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ژورنال
عنوان ژورنال: BMJ
سال: 2004
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.38027.560347.7c